PANDEMIC INFLUENZA A VIRUSES ESCAPE FROM RESTRICTION BY HUMAN MXA THROUGH ADAPTIVE MUTATIONS IN THE NUCLEOPROTEIN.

Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein.

The interferon-induced dynamin-like MxA GTPase restricts the replication of influenza A viruses.We identified adaptive mutations in the nucleoprotein (NP) of pandemic strains A/Brevig Mission/1/1918 (1918) and A/Hamburg/4/2009 (pH1N1) that confer MxA resistance.These resistance-associated amino acids in NP differ between the two strains but form a

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A hybrid anomaly detection method for high dimensional data

Anomaly detection of high-dimensional data is a challenge because the sparsity of the data distribution caused Suction Cups by high dimensionality hardly provides rich information distinguishing anomalous instances from normal instances.To address this, this article proposes an anomaly detection method combining an autoencoder and a sparse weighted

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Exploring resilience among hospital workers: a Bayesian approach

Background and importanceHealthcare professionals face significant workloads, as their roles are among the most demanding and stressful.Resilience serves as a crucial factor in helping them cope with the challenges encountered in their work environment and effectively manage stress.Assessing the level of resilience among healthcare workers and iden

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